No evidence of a significant role for CTLA-4 in multiple sclerosis

No evidence of a significant role for CTLA-4 in multiple sclerosis.

Variation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease and type 1 diabetes. Its role in multiple sclerosis is more controversial. In order to explore this logical candidate more thoroughly, we genotyped 771 multiple sclerosis trio families from the United Kingdom for the 3' untranslated regi...

P 129: The Role of Overexpression Transcription Factor BRN 4 in Multiple Sclerosis

Adult neurogenesis is a process of producing nerve cells from their progenitor that occurs in some areas in the brain such as the hypothalamus. Low activity in this area plays a role in neural degeneration and diseases such as multiple sclerosis, epilepsy and depression. MS is a neurodegenerative disease with a permanent disability that the main reason for it is axonal degeneration and neuronal...

P 34: Evidence of Panax Ginseng in Multiple Sclerosis

Introduction: MS disease destroys the myelin of the central nervous system. MS causing damage to the myelin sheath of the brain and the spinal cord. The mechanism is hurt by the immune system .and disruption of myelin producing cells or disconnect interconnected processes by disconnect inner white. MS is an autoimmune disease when leukocyte antigen system varies autoimmune disease like MS ...

White Matter Diseases YES, Multiple Sclerosis NO, Sjogren - Larsson Syndrome: Another Differential Diagnosis of Multiple Sclerosis

Sjogren-Larsson Syndrome (SLS) is an inherited autosomal recessive neurocutaneous disorder with congenital ichthyosis, spastic diplegia or quadriplegia and mental retardation. We report a case of Sjogren-Larsson Syndrome with clinical profile (mental retardation, ichthyosis, spastic diplegia) and MRI findings such as seen in multiple sclerosis (MS). So this rare syndrome can be another differen...

Significant Increase in the Prevalence of Multiple Sclerosis in Iran in 2011